個人簡介

陳煥春，男，湖北恩施人。星空体育网站入口官网教授、博士生導師，生豬健康養(yang) 殖協同創新中心主任。國務院政府特殊津貼、何梁何利基金科學與(yu) 技術進步獎、中華農(nong) 業(ye) 英才獎、“十一五”國家科技計劃執行突出貢獻獎、湖北省科學技術突出貢獻獎獲得者。德國慕尼黑大學獸(shou) 醫學博士。現任中國獸(shou) 醫協會(hui) 會(hui) 長、星空体育网站入口官网農(nong) 業(ye) 微生物學國家重點實驗室學術委員會(hui) 主任、中國農(nong) 業(ye) 科學院哈爾濱獸(shou) 醫研究所獸(shou) 醫生物技術國家重點實驗室學術委員會(hui) 主任、教育部高等學校教學指導委員會(hui) 動物生產(chan) 類專(zhuan) 業(ye) 教學指導委員會(hui) 主任委員（2013）、國務院突發事件應急專(zhuan) 家委員會(hui) 委員、科技部973傳(chuan) 染病專(zhuan) 家組副組長、863現代農(nong) 業(ye) 技術領域專(zhuan) 家組副組長（2017）、農(nong) 業(ye) 部科技委專(zhuan) 家委員會(hui) 委員、教育部科技委專(zhuan) 家委員會(hui) 委員、農(nong) 業(ye) 部新獸(shou) 藥評審委員會(hui) 委員、農(nong) 業(ye) 部轉基因專(zhuan) 項技術副總師等職。
主持國家自然科學基金、973（2006,2010）、863、國家支撐計劃等重大科研課題50餘(yu) 項，研製出30餘(yu) 種基因工程疫苗和分子診斷試劑盒，獲得了19個(ge) 轉基因安全證書(shu) 、24個(ge) 新獸(shou) 藥注冊(ce) 證書(shu) 、49個(ge) 發明專(zhuan) 利、國家重點新產(chan) 品證書(shu) 5項，獲得國家科技進步二等獎4項、湖北省科技進步一等獎6項、國家教學成果二等獎1項。在國內(nei) 外期刊發表論文600餘(yu) 篇，SCI收錄200餘(yu) 篇，出版專(zhuan) 著3部，參編3部，已培養(yang) 畢業(ye) 博士95人，碩士112人。領導的研究團隊入選國家自然科學基金委員會(hui) 創新群體(ti) 。

教育經曆

1984.10—1989.01 德國慕尼黑大學攻讀博士研究生

工作經曆

1989.02—1993.09 星空体育网站入口官网講師、副教授
1993.10—1994.10 德國慕尼黑大學合作科研
1994.11—2002.12 星空体育网站入口官网教授、博士生導師、畜牧獸(shou) 醫學院院長
2003.01—2007.12 星空体育网站入口官网教授、副校長、中國工程院院士
2008.01—至今星空体育网站入口官网教授、中國工程院院士

研究領域

動物傳(chuan) 染病學

科研成果

A著作類
1.《規模化豬場疫病控製及淨化》主編
2.《獸(shou) 醫手冊(ce) 》主編
3.《偽(wei) 狂犬病》主編
B論文類（部分）
1.Ding Z, An K, Xie LL, Wu W, Zhang RX, Wang D, Fang Y, Chen HC, Xiao SB, Fang LR*. Transmissible gastroenteritis virus infection induces NF-kappa B activation through RLR-mediated signaling. Virology. 2017, 507: 170-178 3.354
2.He W, Zhao ZK, Anees A, Li YC, Ashraf U, Chen Z, Song YF, Chen HC, Cao SB, Ye J*. p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammationin Astrocytes. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3
3.Zheng Chengkun, Zhao Xigong, Zeng Ting, Cao Manman, Xu Jiali, Shi Guolin, Li Jinquan, Chen Huanchun, Bei Weicheng*. Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS microbiology letters.2017, 7 1.7649
4.Sun X, Wang SY, Lin X , Zhao LZ, Zhang D, Yi CY, Sun XM, Chen HC, Jin ML*.Proteome analysis of Duck Tembusu virus (DTMUV)-infected BHK-21 cells.Proteomics.2017, 17:12 4.041
5.Xu Jiali, Zheng Chengkun, Cao Manman, Zeng Ting, Zhao Xigong, Shi Guolin, Chen Huanchun, Bei Weicheng*.The manganese efflux system MntE contributes to the virulence of Streptococcus suis serotype 2.Microbial pathogenesis.2017, 110:23-30 2.009
6.Wang X, Wu CX, Song XR, Chen HC, Liu ZF*. Comparison of pseudorabies virus China reference strain with emerging variants reveals independent virus evolution within specific geographic regions.Virology. 2017, (506): 92-98 3.354
7.Qian Suhong, Fan Wenchun, Liu Tingting, Wu Mengge, Zhang Huawei, Cui Xiaofang, Zhou Yun, Hu Junjie, Wei Shaozhong, Chen Huanchun, Li Xiangmin*, Qian Ping. Seneca Valley Virus suppresses host type I interferon production by targeting adaptor proteins MAVS TRIF and TANK for cleavage. Journal of virology.2017, 4 Journal of virology 3.354
8.Wang SY, Sun X, Yi CY, Zhang D, Lin X, Sun XM, Chen HC, Jin ML*. AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300.Frontiers In Cellular And Infection Microbiology.2017, 7 4.3
9.Rasheed MA, Qi JJ, Zhu XF, He CF, Menghwar H, Khan FA, Gang Z, Zubair M, Hu CM, Chen YY, Chen HC, Guo AZ*. Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3
10.Wang Y, Li JT, Zhang AD, Zhu WF, Zhang Q, Xu ZM, Yan SX, Sun XM, Chen HC, Jin ML*. iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae. Journal Of Proteomics.2017, 160: 28-37 3.914
11.Zou Z, Huang K, Wei YM, Chen HC, Liu ZD, Jin ML*. Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection. Scientific Reports.2017, 7 4.259
12.Peng Z, Liang W, Liu WJ, Chen HC, Wu B*.Genome characterization of Pasteurella multocida subspecies septica and comparison with Pasteurella multocida subspecies multocida and gallicida. Archives Of Microbiology.2017, 199(4): 635-640 1.6
13.Ye Jing, Chen Zheng, Li Yunchuan, Zhao Zikai, He Wen, Zohaib Ali, Song Yunfeng, Deng Chenglin, Zhang Bo, Chen Huanchun, Cao Shengbo*.Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappaB. Journal of virology.2017, 91:8 3.354
14.Zhou YR, Fang LR, Wang D, Cai KM, Chen HC, Xiao SB*. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Stress Granule Formation Depending on Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) in MARC-145 Cells. Frontiers In Cellular And Infection Microbiology.2017, 7 4.3
15.Zhang Shishuo, Wang Ruifang, Su Huijuan, Wang Biaoxiong, Sizhu Suolang, Lei Zhixin, Jin Meilin, Chen Huanchun, Cao Jiyue, Zhou Hongbo*. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS Respectively. International journal of molecular sciences.2017, 18:4 3.226
16.Fan WC, Qian P, Wang DD, Zhi XW, Wei YM, Chen HC, Li XM*. Integrin alpha v beta 3 promotes infection by Japanese encephalitis virus. Research In Veterinary Science. 2017, 111: 67-74 1.298
17.Li YY, Zhou M, Luo ZC , Zhang YC, Cui M , Chen HC, Fu ZF, Zhao L*. Overexpression of Interleukin-7 Extends the Humoral Immune Response Induced by Rabies Vaccination. Journal Of Virology.2017, 91: 7 3.354
18.Ye J, Chen Z, Li YC, Zhao ZK, He W, Zohaib A, Song YF, Deng CL, Zhang B, Chen HC, Cao Shengbo. Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappa B. Journal Of Virology.2017, 91: 8 3.354
19.Liu XK, Yang C, Hu Y, Lei EM, Lin X, Zhao LZ, Zou Z, Zhang AD, Zhou HB, Chen HC, Qian P*, Jin ML*. HIST1H1C Regulates Interferon-beta and Inhibits Influenza Virus Replication by Interacting with IRF3.Frontiers In Immunology. 2017, 8 6.43
20.Li P, Wang R, Dong WQ, Hu LL, Zong BB, Zhang YY, Wang XG, Guo AZ, Zhang AD, Xiang YZ, Chen HC, Tan C*.Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis. Frontiers In Cellular And Infection Microbiology.2017, 7, DOI: 10.3389/fcimb.2017.00065 4.3
21.Yuan FY, Tan C , Liu ZW, Yang K, Zhou D, Liu W, Duan ZY, Guo R, Chen HC, Tian YX* , Bei WC*. The 1910HK/RR two-component system is essential for the virulence of Streptococcus suis serotype 2. Microbial Pathogenesis.2017, 104: 137-145 2.009
22.Sun YX, Deng ML, Peng Z, Hu RM, Chen HC, Wu B*. Genetic and phylogenetic analysis of feline calicivirus isolates in China. Veterinary Journal. 2017, 220: 24-27 1.802
23.Jing HY, Fang LR, Ding Z, Wang D, Hao WQ, Gao L, Ke WT, Chen HC, Xiao SB*. Porcine Reproductive and Respiratory Syndrome Virus nsp1 alpha Inhibits NF-kappa B Activation by Targeting the Linear Ubiquitin Chain Assembly Complex. Journal Of Virology.2017, 91: 3 3.354
24.Wang Z, Li MM, Zhou M, Zhang YJ , Yang J, Cao YD, Wang KL, Cui M, Chen HC, Fu ZF, Zhao L*. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. Journal Of Virology.2017, 91: 3 3.354
25.Fan WC, Liu TT, Li XM, Zhou Y, Wu MG, Cui XF, Chen HC, Qian P*. TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway. Molecular Immunology. 2017, 82: 114-122 3.236
26.Jing Huiyuan, Fang Liurong, Ding Zhen, Wang Dang, Hao Wenqi, Gao Li, Ke Wenting, Chen Huanchun, Xiao Shaobo. Porcine Reproductive and Respiratory Syndrome Virus nsp1alpha Inhibits NF-kappaB Activation by Targeting the Linear Ubiquitin Chain Assembly Complex. Journal of virology.2017, 91:3 3.354
27.Li YT, Ming F, Huang HM, Guo KL , Chen HC, Jin ML, Zhou HB*. Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Scientific Reports.2017, 7 4.259
28.Liu F, Fu JY, Liu CY, Chen J, Sun MH, Chen HC, Tan C*, Wang XR*. Characterization and distinction of two flagellar systems in extraintestinal pathogenic Escherichia coli PCN033. Microbiological.Research.2017, 196: 69-79 3.037
29.Zheng CK, Ren SJ, Xu JL, Zhao XG, Shi GL, Wu JP, Li JQ, Chen HC, Bei WC*. Contribution of NADH oxidase to oxidative stress tolerance and virulence of Streptococcus suis serotype. Virulence.2017, 8(1): 53-65 4.665
30.Chen YY, Wang JR, Ge P, Cao DJ, Miao BP, Robertson I, Zhou X, Zhang L, Chen HC, Guo AZ*. Tissue inhibitor of metalloproteinases 1 a novel biomarker of tuberculosis. Molecular Medicine Reports. 2017, 15(1): 483-487 1.692
31.Farhan, Chen Yingyu, Hu Changmin, Chen Huanchun, Guo Aizhen*. Mycoplasma bovis NADH oxidase functions as both a NADH oxidizing and O2 reducing enzyme and an adhesin. Scientific reports. 2017, 7(1):44 4.2589
32.Peng Z, Liang W, Wang YG, Liu WJ, Zhang HF, Yu T, Zhang AD, Chen HC, Wu B*. Experimental pathogenicity and complete genome characterization of a pig origin Pasteurella multocida serogroup F isolate HN07. Veterinary Microbiology.2017, 198: 23-33 2.628

科研項目

1.國家自然科學基金創新群體(ti) ，動物重要病原分子生物學與(yu) 致病機理，2015-2017
2.農(nong) 業(ye) 部公益性行業(ye) 專(zhuan) 項，副豬嗜血杆菌病和豬傳(chuan) 染性胸膜肺炎防治技術研究與(yu) 示範，2013-2017
3.現代農(nong) 業(ye) 產(chan) 業(ye) 技術體(ti) 係，“十三五”新增崗位科學家，2017-2020

主要獎勵

1.2001年12月10日，國家科學技術進步二等獎，偽(wei) 狂病鄂A株分離鑒定及分子生物學與(yu) 綜合防治研究
2.2005年9月1日，國家級教學成果獎，動物醫學專(zhuan) 業(ye) 人才培養(yang) 方案的改革與(yu) 實踐
3.2007年12月1日，湖北省科學技進步一等獎，禽流感快速檢測技術研究
4.2008年12月1日，湖北省科學技進步一等獎，豬細小病毒病診斷技術、新型疫苗及綜合防製措施研究
5.2007年2月11日，國家科學技術進步二等獎，瘦肉型豬品種（係）及配套技術的創新研究與(yu) 開發
6.2011年12月23日，國家科學技術進步二等獎，動物流感係列快速檢測技術的建立及應用
6.2013年12月1日，湖北省科學技進步一等獎，豬鏈球菌病防控關(guan) 鍵技術研究與(yu) 應用
7.2014年12月1日，湖北省科技進步一等獎，豬傳(chuan) 染性胸膜肺炎防控關(guan) 鍵技術研究與(yu) 應用
8.2015年12月1日，湖北省科技進步一等獎，豬流感病毒致病機製與(yu) 防控技術
9.2016年12月1日，湖北省科技進步一等獎，豬乙型腦炎防控關(guan) 鍵技術研究與(yu) 應用
10.2016年12月1日，國家科學技術進步二等獎，我國重大豬病防控技術集成與(yu) 應用