個人簡介

曹勝波，男，1975年出生於(yu) 湖北房縣。星空体育网站入口官网教授、博士生導師、國家傑出青年基金獲得者（2018）。先後入選國家百千萬(wan) 人才工程（2017）、教育部新世紀優(you) 秀人才（2010）。兼任教育部動物醫學教學指導委員會(hui) 副主任委員、中國畜牧獸(shou) 醫學會(hui) 獸(shou) 醫公共衛生學分會(hui) 副理事長、湖北省畜牧獸(shou) 醫學會(hui) 秘書(shu) 長等。主要從(cong) 事媒介傳(chuan) 播人獸(shou) 共患病致病與(yu) 免疫機製、寵物疫苗、寵物診斷試劑及治療性抗體(ti) 研發。主持承擔國家重點研發計劃、國家自然科學基金等課題。以通訊作者在Science Signaling、Journal of Immunology、Journal of Virology、Journal of Infectious Diseases等期刊發表SCI論文30餘(yu) 篇，獲得湖北省科技進步一等獎1項、新獸(shou) 藥注冊(ce) 證書(shu) 1項。

教育經曆

1994.09 - 1998.06，星空体育网站入口官网，獸(shou) 醫專(zhuan) 業(ye) 畢業(ye) ，農(nong) 學學士
1999.09 - 2002.06，星空体育网站入口官网，預防獸(shou) 醫學專(zhuan) 業(ye) 畢業(ye) ，農(nong) 學碩士
2002.09 - 2005.06，星空体育网站入口官网，動物遺傳(chuan) 育種與(yu) 繁殖（抗病育種方向）專(zhuan) 業(ye) 畢業(ye) ，農(nong) 學博士

工作經曆

1998.7-2002.12，星空体育网站入口官网學生政治輔導員、助教。
2003.01-2006.12，星空体育网站入口官网講師。
2007.01-2011.12，星空体育网站入口官网副教授。
2012.01-現在，星空体育网站入口官网教授、博士生導師。

研究領域

媒介傳(chuan) 播人獸(shou) 共患病致病與(yu) 免疫機製、防控技術與(yu) 產(chan) 品研發；寵物疫苗、診斷試劑及治療性抗體(ti) 研發。

科研成果

A著作類
1.《中國獸(shou) 醫手冊(ce) 》參編。
2.《中國豬病學》參編。
3.《獸(shou) 醫傳(chuan) 染病學》參編。
B論文類
1.Yunchuan Li#, Hao Zhang#, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye*, and Shengbo Cao*.Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection. Frontiers in Immunology. 2017,8:1237.
2.Chong Wang, Nan Zhang, Luting Qi, Jiaolong Yuan, Ke Wang, Kunlun Wang, Sicong Ma, Haili Wang, Wenjuan Lou, Pingdong Hu, Muhammad Awais, Shengbo Cao, Zhen F. Fu and Min Cui*. Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection. Journal of Immunology. 2017,199(9):3094-3105.
3.Wen He, Zikai Zhao, Awais Anees, Yunchuan Li, Zheng Chen, Shengbo Cao, Yunfeng Song, Huanchun Chen, Jing Ye*.p21-activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus mediated Inflammation in Astrocytes. Front Cell Infect Microbiol. 2017,7:271.
4.Jing Ye, Zheng Chen, Yunchuan Li, Zikai Zhao, Wen He, Ali Zohaib, Yunfeng Song, Chenglin Deng, Bo Zhang, Huanchun Chen, Shengbo Cao*. Japanese Encephalitis Virus NS5 Inhibits the Type I Interferon Production by Blocking the Nuclear Translocation of IRF3 and NF-κB. Journal of Virology, 2017, 91(8): e00039-17.
5.Shengfeng Wan#, Usama Ashraf#, Jing Ye, Xiaodong Duan, Ali Zohaib, Wentao Wang, Zheng Chen, Bibo Zhu, Yunchuan Li, Huanchun Chen, Shengbo Cao*. MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS). Oncotarget. 2016, 7(47):76667-76683.
6.Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*.Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Science Signaling, 2016,9(448):ra98.
7.Usama Ashraf , Bibo Zhu, Jing Ye, Shengfeng Wan, Yanru Nie, Zheng Chen, Xiaodong Duan , Hao Zhang, Huanchun Chen, Shengbo Cao*. microRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11.Journal of Virology,2016, 90(9):4780-95.
8.Zheng Chen#, Jing Ye, Usama Ashraf, Yunchuan Li, Siqi Wei, Shengfeng Wan, Ali Zohaib,Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-33a-5p modulates Japanese Encephalitis Virus Replication by targeting Eukaryotic Translation Elongation Factor 1A1. Journal of Virology, 2016,90(7):3722-3734.
9.Bibo Zhu, Jing Ye, Usama Ashraf, Yunchuan Li Huanchun Chen, Yunfeng Song and Shengbo Cao*. Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection. Scientific Reports,2016,6:22581.
10.Jin’e Fang, Huan Li, Dexin Kong, Shengbo Cao, Guiqing Peng, Rui Zhou, Huanchun Chen , Yunfeng Song*. Scientific Reports, 2016, 29;6:34550.
11.Hao Zhang, Jun Sun, Jing Ye, Usama Ashraf, Zheng Chen,Bibo Zhu,Wen He, Qiuping Xu, Yanming Wei,Huanchun Chen, Zhen F. Fu, Rong Liu* and Shengbo Cao*. Quantitative Label-Free Phosphoproteomics Reveals Differentially RegulatedProtein Phosphorylation Involved in West Nile Virus–Induced Host Inflammatory Response. Journal of proteome research. 2015, 14(12):5157-68.
12.Ali Zohaib, Adeel Sarfraz, Qari Muhammad Kaleem, Jing Ye, Mudassar Niaz Mugha, Muhammad Tariq Navid, Faheem Ahmed Khan, Xiaodong Duan, Bibo Zhu, Shengfeng Wan and Shengbo Cao*.The Yin and Yang of Antiviral Innate Immunity in Central Nervous System. Current Pharmaceutical Design,2016,22(6):648-55.
13.Bibo Zhu, Jing Ye, Yanru Nie, Usama Ashraf,, Ali Zohaib, Xiaodong Duan, Zhen F. Fu, Yunfeng Song, Huanchun Chen, Shengbo Cao *.MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. Journal of Immunology 2015,195(5):2251-62.
14.Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015, 1;10(5):e0125727.
15.Qian Dong, Qiuping Xu, Xindi Ruan, Shaomei Huang, Shengbo Cao*. Monoclonal Antibodies Against NS2B of Japanese Encephalitis Virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2015,34(2):96-100.
16.Fang Li#, Yueyun Wang#, Lan Yu#, Shengbo Cao, Ke Wang, Jiaolong Yuan, Chong Wang, Kunlun Wang, Min Cui*, Zhen F. Fu. Viral Infection of the Central Nervous System and Neuroinflammation Precede Blood-Brain Barrier Disruption during Japanese Encephalitis Virus Infection. Journal of Virology. 2015,89(10):5602-14.
17.Ali Zohaib#, Xiaodong Duan#, Bibo Zhu, Jing Ye, ShengfengWan, Huanchun Chen, Xueqin Liu*, Shengbo Cao*. The Role of Ubiquitination in Regulation of Innate Immune Signaling. Current Issues in Molecular Biology. 2015,18:1-10 .
18.Usama Ashraf, Jing Ye, Xindi Ruan, Shengfeng Wan, Bibo Zhu, and Shengbo Cao* Usutu virus: an emerging flavivirus in Europe. Viruses-Basel. 2015, 7(1):219-38.
19.Yang Yang#, Ying Huang#, Clement W. Gnanadurai#, Shengbo Cao, Xueqin Liu, Min Cui*, and Zhen F. Fu*.The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA. Journal of Virology. 2015,89(4):2157-69.
20.Yumeng Zhang#, Huan Li#, Guiqing Peng, Yong Zhang, Xiao Gao, Shaobo Xiao, Shengbo Cao, Huanchun Chen, Yunfeng Song. Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus nonstructural protein 10. Journal of General Virology. 2015,96(Pt 3):547-52.
21.Xiaodong Duan, Ali Zohaib, Yunchun Li, Bibo Zhu, Jing Ye, Shengfeng Wan, Qiuping Xu, Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes. Cellular Signalling.2015, 27(1) : 61-68.
22.Ali Zohaib, Muhammad Saqib**, Muhammad Hammad Hussain, Steeve Lowenski, Sylvie Lecollinet, Cécile Beck, Awais-ur-Rehman Sial, M. Nadeem Asi, M. Khalid Mansoor, Muhammad Saqalein, Khurram Ashfaq, Muhammad Saleem, Ghulam Muhammad and Shengbo Cao*. High Prevalence of West Nile Virus in Equines from the two provinces of Pakistan Epidemiology and Infection,2014, 31:1-5（IF2013=2.46）
23.Rong Jiang#, Jing Ye#, Bibo Zhu, Yunfeng Song, Huanchun Chen,Shengbo Cao*.Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia Following Japanese Encephalitis Virus Infection. Journal of Immunology Research, 2014,2014：787023.
24.Jing Ye#, Rong Jiang#, Min Cui, Bibo Zhu, Leqiang Sun, Yueyun Wang, Ali Zohaib, Qian Dong, Xindi Ruan, Yunfeng Song, Wen He, Huanchun Chen, Shengbo Cao*. Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. Journal of Infectious Diseases.2014, 15;210(6):875-89.
25.XiaoDan Li#, XiaoFeng Li#, HanQing Ye, ChengLin Deng, Qing Ye, Chao Shan, BaoDi Shang, LinLin Xu, ShiHua Li, Shengbo Cao, Zhiming Yuan, PeiYong Shi, ChengFeng Qin*, and Bo Zhang*. Recovery of a chemically synthesized Japanese encephalitis virus revealed two critical adaptive mutations in NS2B and NS4A. Journal of General Virology 2014, 95(4):806-15.
26.Jin’e Fang#, Leqiang Sun#, Guiqing Peng, Jia Xu, Rui Zhou, Shengbo Cao, Huanchun Chen, Yunfeng Song*. Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280. PLoS ONE, 2013, 8(11): e78425.
27.Yang Yang#, Ali Zohaib#, Gong Chen, Jing Ye, Shengbo Cao*. DC-SIGN Increase Japanese Encephalitis Virus Infection. Pakestan Vet J.2013, 33(4): 408-412.
28.Jing Ye, Zheng Chen, Bo Zhang, Huan Miu, Ali Zohaib, Qiuping Xu, Huanchun Chen*, Shengbo Cao *. Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication. Plos One,2013, 8(9):e75188.
29.Jin’e Fang, Huan Li, Guiqing Peng, Shengbo Cao, F. Fu Zhen, Huanchun Chen, Yunfeng Song∗. Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase. Journal of Virological Methods. 2013;194(1-2):33-8.
30.Zai J, Mei L, Wang C, Cao S, Fu ZF, Chen H, Song Y*. N-glycosylation of the premembrane protein of Japanese encephalitis virus is critical for folding of the envelope protein and assembly of virus-like particles. Acta Virologica. 2013;57(1):27-33.
31.Rui Jin, Wandi Zhu, Shengbo Cao, Rui Chen, Hui Jin, Yang Liu, Shaobo Wang, Wei Wang* and Gengfu Xiao* Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PLoS One. 2013;8(1):e52909.
32.Xindi Ruan，Shaomei Huang, Lin Shao, Jing Ye, Zheng Chen, Huanchun Chen and Shengbo Cao*.Monoclonal antibodies against NS4B protein of Japanese encephalitis virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.2013,32(6):382-385.
33.Jing Ye, Bibo Zhu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*. Immune evasion strategies of flaviviruses. Vaccine, 2013,31(3) : 461–471.
34.Bibo Zhu, Jing Ye, Ping Lu, Rong Jiang, Xiaohong Yang, Zhen F Fu, Huanchun Chen, Shengbo Cao*. Induction of Antigen-Specific Immune Responses in Mice by Recombinant Baculovirus Expressing Premembrane and Envelope Proteins of West Nile Virus. Virology Journal. 2012,9:132.
35.Zheng Chen,Lin Shao, Jing Ye, Yongmao Li, Shaomei Huang, Huanchun Chen and Shengbo Cao*. Generation and characterization of the monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus. Hybridoma. 2012,31(2):137-41.
36.Li Mei#, Peng Wu#, Jing Ye, Lin Shao, Shaomei Huang,Yaoming Li, Xiaohong Yang, Huanchun Chen and Shengbo Cao*. Development and Application of an Antigen Capture ELISA Assay for Diagnosis of Japanese encephalitis Virus in Swine，Human and Mosquito. Virology Journal. 2012, 9:4.

科研項目

1. 重要神經嗜性人獸(shou) 共患病免疫與(yu) 致病機製研究，國家重點研發計劃，2016-2020，項目主持
2. LncRNA調控乙型腦炎病毒介導炎症反應的分子機製，國家自然科學基金，2016-2019，項目主持
3. 乙型腦炎病毒激活小膠質細胞的分子機製，國家自然科學基金，2012-2015，項目主持
4. 乙型腦炎病毒誘導炎症損傷(shang) 的分子機製，教育部新世紀優(you) 秀人才支持計劃，2011-2013，項目主持
5. 豬乙型腦炎高效疫苗與(yu) 診斷試劑產(chan) 業(ye) 化，農(nong) 業(ye) 公益性行業(ye) 專(zhuan) 項，2012-2016，課題主持
6. II型包膜病毒的入侵機製－乙型腦炎病毒入侵機製，973，2009-2013，項目骨幹
7. 豬流行性乙型腦炎綜合防控技術體(ti) 係研究與(yu) 示範，農(nong) 業(ye) 公益性行業(ye) 專(zhuan) 項，2008-2010，課題主持
8. 非洲豬瘟等重要外來動物疫病綜合防控技術研究，農(nong) 業(ye) 公益性行業(ye) 專(zhuan) 項，2009-2013，課題主持
9. 乙型腦炎病毒強弱毒株在小鼠體(ti) 內(nei) 增殖與(yu) 分布規律研究，國家自然科學基金，2007-2009，項目主持

主要獎勵

1. 2016年獲湖北省科技進步一等獎，排名1
2. 2013年獲湖北省第十一屆青年科技獎
3. 2012年獲武漢市第三屆青年科技獎
4. 2007年獲湖北省科技進步一等獎，排名7