師資隊伍
國家傑出青年基金獲得者
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肖少波，1969年出生，博士，星空体育网站入口官网二級崗教授、博士生導師，國家傑出青年基金獲得者(2012)、教育部“長江學者”特聘教授、湖北省自然科學基金創新研究群體(ti) 學術帶頭人。先後入選國家農(nong) 業(ye) 科研傑出人才、國家中青年科技創新領軍(jun) 人才（2013）、國家百千萬(wan) 人才工程（2013）、教育部新世紀優(you) 秀人才（2007）、武漢市黃鶴科技英才等人才計劃，榮獲“國家有突出貢獻中青年專(zhuan) 家”（2013）等榮譽稱號，享受國務院政府特殊津貼。兼任中國免疫學會(hui) 獸(shou) 醫免疫學專(zhuan) 業(ye) 委員會(hui) 委員、湖北省微生物學會(hui) 畜牧獸(shou) 醫微生物學專(zhuan) 業(ye) 委員會(hui) 主任，《病毒學報》、《中國動物傳(chuan) 染病學報》等雜誌編委。主要開展豬繁殖與(yu) 呼吸綜合征病毒、豬腸道冠狀病毒等重要動物病毒的病原學與(yu) 流行病學、病毒與(yu) 宿主免疫係統的相互作用、新型疫苗與(yu) 診斷技術研究。先後承擔國家自然科學基金重大項目、國家傑出青年基金、973計劃、863計劃、國家科技支撐計劃、教育部科學技術研究重大項目等科研課題，在Journal of Virology (JVI)、Journal of Biological Chemistry (JBC)、Journal of Proteome Research (JPR) 等國際期刊上發表SCI論文130餘(yu) 篇，申報/獲得國家發明專(zhuan) 利20餘(yu) 項，新獸(shou) 藥注冊(ce) 證書(shu) 2項。
2001/09 – 2004/06，星空体育网站入口官网，動物醫學院，博士1997/09 – 2000/12，星空体育网站入口官网，動物醫學院，碩士1988/09 – 1992/06，星空体育网站入口官网，畜牧獸(shou) 醫學院，本科
2011/01 – 至今， 星空体育网站入口官网，動物醫學院，教授2011/06 – 2011/07，美國佐治亞(ya) 大學，獸(shou) 醫學院，訪問學者2006/07 – 2010/12，星空体育网站入口官网，動物醫學院，副教授2004/11 – 2005/04，德國哥廷根大學，獸(shou) 醫研究所，訪問學者2004/07 – 2006/06，星空体育网站入口官网，動物醫學院，講師1992/07 – 1997/08，湖北省沙市農(nong) 場，技術員
1. 病原學與(yu) 流行病學2. 病毒與(yu) 宿主免疫係統相互作用3. 新型疫苗與(yu) 診斷試劑創製
1.Xiao S, Chen H, Fang L, Liu C, Zhang H, Jiang Y, Hong W. Comparaison of immune resp[onses and protective efficacy of suicidal DNA vaccine and conventional DNA vaccine encoding glycoprotein C of pseudorabies virus in mice. Vaccine. 2004, 22(3-4):345-351. 2.Jiang Y, Xiao S, Fang L, Yu X, Song Y, Niu C, Chen H. DNA vaccines co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus (PRRSV) display enhanced immunogenicity. Vaccine. 2006, 24(15):2869-2879. 3.Fang L, Jiang Y, Xiao S, Niu C, Zhang H, Chen H. Enhanced immunogenicity of the modified GP5 of porcine reproductive and respiratory syndrome virus. Virus Genes. 2006, 32(1):5-11. 4.Yu X, Xiao S, Fang L, Jiang Y, Chen H. Enhanced immunogenicity to food-and-mouth disease virus in mice vaccination with alphaviral replicon-based DNA vaccine expressing the capsid precursor polypeptide (P1). Virus Genes. 2006, 33(3):337-344. 5.Xiong F, Xiao S, YU, Li W, Zheng H, Shang Y, Peng F, Zhao C, Zhou W, Chen H, Fang L, Zhang C. Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport. BMC Neurosci. 2007, 8:50. 6.Xiong F, Xiao S, Peng F, Yu M, Yuan Y, Chen H, Fang L, Zhang C. HSV-VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice. Hum Gene Ther. 2007, 18(6):490-501. 7.Jiang Y, Fang L, Xiao S, Zhang H, Pan Y, Luo R, Li B, Chen H. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(3):547-560. 8.Wang S, Fang L, Fan H, Jiang Y, Pan Y, Luo R, Zhao Q, Chen H, Xiao S. Construction and immunogenicity of pseudotype baculovirus expressing GP5 and M protein of porcine reproductive and respiratory syndrome virus. Vaccine. 2007, 25(49):8220-8227. 9.Wang D, Fang L, Li T, Luo R, Xie L, Jiang Y, Chen H, Xiao S. Molecular cloning and functional characterization of porcine IFN-β promoter stimulator 1 (IPS-1). Vet Immunol Immunopathol. 2008, 125(3-4):344-353. 10.Fan H, Pan Y, Fang L, Wang D, Wang S, Jiang Y, Chen H, Xiao S. Construction and immunogenicity of recombinant pseudotype baculovirus expressing the capsid protein of porcine circovirus type 2 in mice. J Virol Methods. 2008, 150(1-2):21-26. 11.Fan H, Xiao S, Tong T, Wang S, Xie L, Jiang Y, Chen H, Fang L. Immunogenicity of porcine circovirus type 2 capsid protein targeting to different subcellular compartments. Mol Immunol. 2008, 45(3):653-660. 12.Luo R, Xiao S, Jiang Y, Jin H, Wang D, Liu M, Chen H, Fang L. Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway. Mol Immunol. 2008, 45(10):2839-2846. 13.Jiang Y, Fang L, Xiao S, Li B, Pan Y, Luo R, Chen H. A suicidal DNA vaccine co-expressing two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus antigens induce protective responses. Biotechnol Lett. 2009, 31(4):509-518. 14.Li B, Xiao S, Wang Y, Xu S, Jiang Y, Chen H, Fang L. Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene. Vaccine. 2009, 27(13): 1957-1963. 15.Pan Y, Zhao Q, Fang L, Luo R, Chen H, Xiao S. Efficient gene delivery into mammalian cells by recombinant baculovirus containing a hybrid cytomegalovirus promoter/Semeliki Forest virus replicon. J Gene Med. 2009, 11(11):1030-1038. 16.Wu Q, Fang L, Wu X, Li B, Luo R, Yu Z, Jin M, Chen H, Xiao S. A pseudotype baculovirus-mediated vaccine confers protective immunity against lethal challenge with H5N1 avian influenza virus in mice and chickens. Mol Immunol. 2009, 46(11-12):2210-2217. 17.Huang Q, Yao Q, Fan H, Xiao S, Si Y, Chen H. Development of a vaccine vector based on a subgenomic replicon of porcine reproductive and respiratory syndrome virus. J Virol Methods. 2009 Sep;160(1-2):22-8. 18.Li B, Fang L, Xu Z, Liu S, Gao J, Jiang Y, Chen H, Xiao S. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis. 2009, 15(12):2032-2035. 19.Wang D, Fang L, Luo R, Ye R, Fang Y, Xie L, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels. Biochem Biophys Res Commun. 2010, 399(1):72-78. 20.Li B, Fang L, Liu S, Zhao F, Jiang Y, Chen H, Xiao S. The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009. Vet Microbiol. 2010, 10.1016/j.vetmic.1010.05.011. 21.Jiang Y, Fang L, Luo R, Xiao S, Chen H. N-acetylpenicillamine inhibits the replication of porcine reproductive and respiratory syndrome virus in vitro.Vet Res Commun. 2010, 34(7):607-617. 22.Liu W, Fang L, Li S, Li Q, Zhou Z, Feng Z, Luo R, Shao G, Wang L, Chen H, Xiao S. Complete genome sequence of Mycoplasma hyorhinis strain HUB-1. J. Bacteriol. 2010, 192(21): 5844-584523.Pan Y, Fang L, Fan H, Luo R, Zhao Q, Chen H, Xiao S. Antitumor effects of a recombinant pseudotype baculovirus expressing Apoptin in vitro and in vivo. Int J Cancer. 2010, 126(11): 2741-2751. 24.Xie L, Liu M, Fang L, Cai K, Wang D, Chen H, Xiao S. Molecular cloning and functional characterization of porcine stimulator of interferon genes (STING). Dev Comp Immunol. 2010, 34(8):847-854. 25.Xie L, Fang L, Wang D, Luo R, Cai K, Chen H, Xiao S. Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI). Dev Comp Immunol. 2010, 34(3):293-299. 26.Xu Z, Chang X, Xiao S, Chen H, Zhou R. Evidence for the adaptive evolution of ORF5 gene of Porcine reproductive and respiratory syndrome virus isolated in China. Acta Virol. 2010, 54(4):281-285. 27.Wang Y, Luo R, Fang L, Wang D, Bi J, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus (PRRSV) infection activates chemokine RANTES in MARC-145 cells. Mol Immunol. 2011, 48(4): 586-59128.Liu W, Feng Z, Fang L, Zhou Z, Li Q, Li S, Luo R, Wang L, Chen H, Shao G, Xiao S. Complete Genome Sequence of Mycoplasma hyopneumoniae Strain 168. J. Bacteriol. 2011, 193(4): 1016-1017. 29.Wang D, Fang L, Li P, Chen Q, Luo R, Chen H, Xiao S. Molecular cloning of the porcine RANTES promoter: functional characterization of dsDNA/dsRNA response elements in PK-15 cells. Dev Comp Immunol. 2011, 35(3): 345-351. 30.Wang D, Fang L, Zhao F, Luo R, Chen H, Xiao S. Molecular cloning, expression and antiviral activity of porcine interleukin-29 (poIL-29). Dev Comp Immunol. 2011, 35(3): 378-784. 31.Zeng S, Wang D, Fang L, Ma J, Song T, Zhang R, Chen H, Xiao S. Complete coding sequences and phylogenetic analysis of porcine bocavirus (PBoV). J Gen Virol. 2011, 92(4): 784-788. 32.Luo R, Fang L, Jiang Y, Jin H, Wang Y, Wang D, Chen H, Xiao S. Activation of NF-κB by necleocapsid protein of the Porcine reproductive and respiratory syndrome virus (PRRSV). Virus Genes. 2011, 42(1):76-81. 33.Liu M, Tan C, Fang L, Xiao S, Chen H. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet Microbiol. 2011, 150(1-2): 753-758. 34.Wang D, Fang L, Li P, Sun L, Fan J, Zhang Q, Luo R, Liu X, Li K, Chen H, Chen Z, Xiao S. The leader proteinase of foot-and-mouth disease virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. J. Virol. 2011, 85(8): 3758-3766. 35.Huang H, Xiao S, Qin J, Jiang Y, Yang S, Li T, Gao Y, Li Z, Li T, Su X, Ruan Y, Xu F, Wang H, Chen H, Xia X. Construction and immunogenicity of a recombinant pseudotype baculovirus expressing the glycoprotein of rabies virus in mice. Arch Virol. 2011, 156(5):753-758. 36.Xu Z, Xiao S, Xu P, Xie T, Cao L, Wang D, Luo R, Zhong Y, Chen H, Fang L. miR-365, a novel negative regulator of IL-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem. 2011, 286(24):21401-21412. 37.Wang D, Fang L, Bi J, Chen Q, Cao L, Luo R, Chen H, Xiao S. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells. Virus Genes. 2011,42(3): 388-39338.Liu M, Fang L, Tan C, Long T, Chen H, Xiao S. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011, 12(1):25339.Li B, Fang L, Guo X, Gao J, Song T, Bi J, He K, Chen H, Xiao S. Epidemiology and evolutionary characteristics of the porcine reproductive and respiratory syndrome virus in China between 2006 and 2010. J Clin Microbiol. 2011, 49(9): 3175-3183. 40.Wang D, Fang L, Liu L, Zhong H, Chen Q, Luo R, Liu X, Zhang Z, Chen H, Xiao S. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway. Mol Immunol. 2011, 49(1-2): 407-412. 41.Fang Y, Fang L, Wang Y, Lei Y, Luo R, Wang D, Chen H, Xiao S. Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation. Virol J. 2012, 9: 83. 42.Song T, Fang L, Zeng S, Li B, Chen H, Xiao S. Complete genome sequence of porcine reproductive and respiratory syndrome virus isolated from piglet stool sample. J Virol. 2012, 86(7):4040-4041. 43.Liu W, Fang L, Li M, Li S, Guo S, Luo R, Feng Z, Li B, Zhou Z, Shao G, Chen H, Xiao S. Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome. PLoS One. 2012, 7(4):e35698. 44.Cao J, Li B, Fang L, Chen H, Xiao S. Pathogenesis on nonsuppurative encephalitis caused by highly pathogenic porcine reproductive and respiratory syndrome virus). J Vet Diagn Invest. 2012, 24(4):767-771. 45.Lin Y, Xiao S, Zeng Y, Song T, Zeng S, Chen H, Fang L. Complete Genome Sequence of Porcine Kobuvirus Strain W
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